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| Description |
CD105 MicroBeads can be used for the isolation of marrow stromal cells MSCs) from bone marrow aspirate as well as endothelial cells from endothelial tissue. The CD105 antigen serves as a receptor for the growth and differentiation factors TGF-β1 and TGF-β3. The CD105 MicroBeads recognize the same molecular antigen as anti-SH2 antibodies – the most commonly employed antibodies for MSC definition1.
CD105 is further expressed on mature endothelial cells – where it is more commonly known as endoglin – and on some leukemic cells of B lymphoid and myeloid origin. |
| Applications |
| CD105+ cells from bone marrow can be used for studies on mesengenesis and for in vitro investigations on hematological disorders.1 CD105+ bone marrow cells also show multipotent differentiation in vitro2 and the capacity to form bone in vivo without prior cultivation or differentiation.3 |
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| Figure 1 |
| Immunomagnetically selected CD105+ cells after 25 days in culture. Cells were isolated from the bone marrow aspirate of an acute myeloid leukemai patient.2 |
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| MACS References |
| 1. Campioni et al. (2002) Stem cell Customer Report 1: 6–8. |
| 2. Majumdar et al. (2000) J. Cell. Physiol. 185: 98–106.[997] |
| 3. Aslan et al. (2006) Stem Cells 24: 1728–1737 |
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