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| Overview |
| Anti-HLA-DR MicroBeads have been developed for positive selection or depletion of antigen-presenting cells from PBMCs, cord blood, bone marrow, and tissue. |
| Details |
Background information
The HLA-DR antigen is constitutively expressed on professional antigen-presenting cells (dendritic cells, B cells, monocytes/macrophages), and its expression is further up-regulated upon activation. On T cells, NK cells, hematopoietic precursor cells, and some epithelial cells the expression of HLA-DR is induced by cell activation.
Downstream applications
HLA-DR–positive cells are isolated, for example, for serological typing of HLA class II molecules or studies on antigen presentation. |
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| Figure 1 |
| Separation of human PBMCs using Anti-HLA-DR MicroBeads and MiniMACS™ Separator with an MS Column. Cells are stained with Anti-HLA-DR-FITC. |
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