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| Description |
| Clone MZ18-24A9 is specific for human CD49d, but also cross-reacts with rhesus monkey (Macaca mulatta) and cynomolgus monkey (Macaca fascicularis) cells. CD49d, also known as the α4 integrin chain or VLA-4α chain, is a 150 kDa cell adhesion protein that is directly involved in mononuclear leukocyte trafficking. Dimerized with β7 integrin, the resulting α4β7 integrin binds VCAM-1 (CD106), MAdCAM-1, and fibronectin. In T cells, on ligation of MAdCAM-1, α4β7 integrin also provides costimulation of T cell receptor/CD3–mediated signaling. CD49d is expressed on most mononuclear leukocytes, both in circulation or in lymphoid or other tissues, as well as on eosinophils and basophils. |
| Applications |
| Identification and enumeration of CD49d+ non-human primate cells by flow cytometry or fluorescence microscopy. |
| Clone | Isotype |
| MZ-24A9 | Mouse IgG2b |
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| Figure 1 |
| Rhesus monkey PBMCs were stained with CD49d-PE and CD4-APC and analyzed by flow cytometry. |
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| Figure 2 |
| Cynomolgus monkey PBMCs were stained with CD49d-PE and CD4-APC and analyzed by flow cytometry. |
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| Products |
| CD49d-FITC, human |
- for 100 tests (1)
Download data sheet
130-093-283
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| CD49d-PE, human |
- for 100 tests (1)
Download data sheet
130-093-282
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| CD49d-APC, human |
- for 100 tests (1)
Download data sheet
130-093-281
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| CD49d-Biotin, human |
- for 100 tests (2)
Download data sheet
130-093-280
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| CD49d pure, human |
- 100 µg in 1 mL.
Download data sheet
130-093-279
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| (1) One test corresponds to fluorescent labeling of up to 107 cells in a total volume of 100 µL. |
| (2) One test corresponds to labeling of up to 107 cells in a total volume of 100 µL. |
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