|
|
 |
|
| Description |
The Anti-FoxP3 antibody specifically recognizes the forkhead/winged-helix transcriptional regulator FoxP3, also known as FORKHEAD BOX P3, SCURFIN, and JM2. It is expressed predominantly in Tregs and is a major marker and functional regulator of T reg cell development and function.1,2 Mutations in the FoxP3 gene are linked to the autoimmune manifestations observed in the Scurfy mouse and humans with immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome.3,4 Studies in mice have shown that FoxP3-deficient animals lack Treg cells, whereas overexpression of the FoxP3 protein leads to profound immune suppression.
Clone 3G3 has been tested to cross-react with FoxP3 on rhesus monkey (Macaca mulatta) and cynomolgus (Macaca fascicularis) cells.
The FoxP3 Staining Buffer Set is optimized for intracellular staining of FoxP3 with clone 3G3. |
| Applications |
| The antibody is suitable for intracellular staining of FoxP3 in human, mouse, and non-human primate cells. |
| Clone | Isotype |
| 3G3 | Mouse IgG1 |
| |
| Figure 1 |
| Rhesus monkey PBMCs were stained with CD4-FITC and CD25-APC. Cells were fixed, permeabilized and intracellularly stained with Anti-FoxP3-PE using the FoxP3 Staining Buffer Set. Cells were analyzed by flow cytometry. |
 |
|
|
|
|
| My favorites |
| Your current favorite list is empty. |
| Products |
| Anti-FoxP3-PE, human and mouse |
- for 100 tests (1)
Download data sheet
130-093-014
|
| Anti-FoxP3-APC, human and mouse |
- for 100 tests (1)
Download data sheet
130-093-013
|
| FoxP3 Staining Buffer Set |
- for 100 tests
Download data sheet
130-093-142
|
| (1) One test corresponds to fluorescent labeling of 106 cells in a total volume of 100 µL. |
|
| References |
| 1. Hori et al. (2003) Science 299: 1057–1061. |
| 2. Walker et al. (2003) J. Clin. Invest. 112: 1437–1443. |
| 3. Sakaguchi et al. (1995) J. Immunol. 155: 1151–1164. |
| 4. Lundsgaard et al. (2005) Diabetes 54: 306–310. |
|
|