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| Description |
Clone AF12-7H3 is specific for human CD56 but also recognizes a subset of PBMCs from rhesus monkey (Macaca mulatta) and cynomolgus monkey (Macaca fascicularis).
The CD56 antigen is a glycoprotein of the Ig-superfamily. The monoclonal antibody CD56 (clone AF12-7H3) recognizes the 140 kDa isoform of N-CAM (Neural Cell Adhesion Molecule) expressed in human blood on essentially all resting and activated NK cells and on a minor subset of CD3+ T cells. The monoclonal antibody AF12-7H3 recognizes a CD56 epitope which is distinct from the epitopes recognized by the CD56-specific monoclonal antibodies NCAM16.2 and B159.
CD56 has been reported to be expressed on rhesus monkey monocytes and on a minor subset of CD8+CD16– NK cells. However, the vast majority of rhesus monkey NK cells do not express CD56.1,2 |
| Applications |
| The CD56 antibody can be used to identify and enumerate CD56+ cells by flow cytometry or fluorescence microscopy. |
| Clone | Isotype |
| AF12-7H3 | Mouse IgG1 |
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| Figure 1 |
| Rhesus monkey PBMCs were stained with CD56-PE and CD14-FITC and analyzed by flow cytometry. |
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| Figure 2 |
| Cynomolgus monkey PBMCs were stained with CD56-PE and CD14-APC and analyzed by flow cytometry. |
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| Products |
| CD56-PE, human |
for 100 tests (1)
Download data sheet
130-090-755
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| CD56-APC, human |
for 100 tests (1)
Download data sheet
130-090-843
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| CD56 pure, human |
50 ÎĽg in 1 mL
Download data sheet
130-090-955
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| (1) One test corresponds to fluorescent labeling of up to 107 cells in a total volume of 100 ÎĽL. |
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| MACS References |
| 1. Carter et al. (1999) Cytometry 37: 41–50.[8299] |
| 2. Webster and Johnson (2005) Immunology 115: 206–214.[8298] |
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