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| Description |
The CD39 antibody specifically recognizes the membrane-bound human CD39 antigen, which is expressed on an effector/memory-like subset of FoxP3+ regulatory T cells1. CD39 is an ectonucleotidase and catalyzes the hydrolysis of extracellular nucleotides, for example, ATP. In concert with CD73, which is an ecto-5’-nucleotidase, this can lead to the production of adenosine.
High extracellular ATP concentrations indicate tissue injury and cell death and induce various pro-inflammatory responses in immune cells.
Through its enzymatic activity, CD39 can contribute to the suppressive function of regulatory T cells, for example, by eliminating extracellular ATP or by generating adenosine, which has suppressive effects on various immune cells.
This antibody is tested to cross-react with rhesus monkey (Macaca mulatta) cells. |
| Applications |
| The CD39 antibody can be used to identify and enumerate CD39+ regulatory T cells and other cells expressing CD39. |
| Clone | Isotype |
| MZ18-23C8 | mouse IgG1 |
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| Figure |
| Rhesus monkey PBMCs were stained with CD39-APC and CD4-FITC and analyzed by flow cytometry. |
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| Products |
| CD39-FITC, human |
- for 100 tests (1)
Download data sheet
130-093-502
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| CD39-PE, human |
- for 100 tests (1)
Download data sheet
130-093-503
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| CD39-APC, human |
- for 100 tests (1)
Download data sheet
130-093-504
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| CD39-Biotin, human |
- for 100 tests (2)
Download data sheet
130-093-505
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| CD39 pure, human |
- 100 ÎĽg in 1 mL
Download data sheet
130-093-506
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| (1) One test corresponds to fluorescent labeling of up to 107 cells in a total volume of 100 ÎĽL. |
| (2) One test corresponds to labeling of up to 107 cells in a total volume of 100 ÎĽL. |
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| References |
| 1. Borsellino et al. (2007) Blood 110: 1225–1232.[10229] |
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