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| Description |
| The CD105 antibody (clone MJ7/18) recognizes the CD105 antigen, also known as endoglin. CD105 is a proliferation-associated and hypoxia-inducible protein, abundantly expressed in angiogenic endothelial cells. In mouse bone marrow, CD105 is also expressed on a population of Sca-1+ hematopoietic stem cells (HSCs). This population has a long-term repopulating (LTR) capacity and is therefore termed LTR-HSCs1,2. Furthermore, on liver sinusoidal endothelial cells (LSEC), CD105 is co-expressed with CD146 (LSEC). |
| Applications |
| The CD105 antibody can be used to identify and enumerate CD105+ cells by flow cytometry or fluorescence microscopy. |
| Clone | Isotype |
| MJ7/18 | Rat IgG2a |
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| Figure 1 |
| Mouse bone marrow cells were stained with CD105-PE (A) or CD105-APC (B). Cells labeled with CD105-Biotin were stained with Anti-Biotin-PE (C). Cells were counterstained with Anti-Sca-1-FITC and analyzed by flow cytometry. |
| A |
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| B |
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| C |
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| Products |
| CD105-PE, mouse |
- for 100 tests (1)
Download data sheet
130-092-929
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| CD105-APC, mouse |
- for 100 tests (1)
Download data sheet
130-092-930
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| CD105-Biotin, mouse |
- for 100 tests (2)
Download data sheet
130-092-927
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| CD105 pure, mouse |
- 100 ÎĽg in 1 mL
Download data sheet
130-092-926
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| (1) One test corresponds to fluorescent labeling of up to 107 cells in a total volume of 100 ÎĽL. |
| (2) One test corresponds to labeling of up to 107 cells in a total volume of 100 ÎĽL. |
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| References |
| 1. Chen et al. (2002) Proc. Natl. Acad. Sci. USA 99: 15468–15473. |
| 2. Chen et al. (2003) Immunity 19: 525–533. |
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