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| Description |
Clone FGK45.5 recognizes the mouse CD40 antigen, a 40–50 kDa glycoprotein and member of the tumor necrosis factor receptor (TNFR) family. CD40 is expressed on B lymphocytes, macrophages, and dendritic cells. It is an important costimulatory molecule for B cells as well as dendritic cells, monocytes, and other antigen-presenting cells (APCs). The interaction of CD40 on B cells with its ligand CD154 is involved in B cell activation and differentiation; engagement of CD40 on dendritic cells leads to maturation.
Clone FGK45 can be used for blocking of CD40/CD154 interaction and for in vitro and in vivo activation of CD40 expressing APCs. |
| Applications |
| The antibody is suitable for the identification and enumeration of CD40+ cells by flow cytometry and fluorescence microscopy. The functional grade antibody can be used for in vivo or in vitro functional assays or for blocking of the CD40/CD154 interaction. |
| Clone | Isotype |
| FGK45.5 | Rat IgG2a |
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| Figure 1 |
| Mouse splenocytes were stained with CD40-PE and CD19-APC and analyzed by flow cytometry. |
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| Products |
| CD40-PE, mouse |
- For 100 tests (1)
Download data sheet
130-092-848
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| CD40-APC, mouse |
- For 100 tests (1)
Download data sheet
130-092-847
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| CD40-Biotin, mouse |
- For 100 tests (2)
Download data sheet
130-092-846
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| CD40 pure, mouse - functional grade |
- 1 mg in 0,5 mL
Download data sheet
130-093-023
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- 100 ÎĽg in 1 mL
Download data sheet
130-093-022
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| (1) One test corresponds to fluorescent labeling of up to 107 cells in a total volume of 100 µL. |
| (2) One test corresponds to labeling of up to 107 cells in a total volume of 100 µL. |
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