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| Description |
| Clone 3C1 recognizes mouse CD117, a 145 kDa cell surface glycoprotein belonging to the Class III receptor tyrosine kinase family. CD117 is also known as c-kit and stem cell factor (SCF) receptor. It is expressed on the majority of hematopoietic progenitor cells including multipotent hematopoietic stem cells as well as committed myeloid, erythroid, and lymphoid precursor cells. In addition to their hematopoietic cell differentiation potential, CD117+ stem cells from murine bone marrow were reported to be capable of differentiation into smooth muscle cells, myocytes, and endothelial cells in vivo.1,2 CD117 is also expressed on some mature hematopoietic cells, for example, mast cells. |
| Applications |
| The CD117 antibody can be used to identify and enumerate CD117+ cells by flow cytometry or fluorescence microscopy. This antibody is suitable for MACS® Control applications. For further details, please refer to the data sheet of the separation reagent. |
| Clone | Isotype |
| 3C1 | Rat IgG2b |
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| Figure 1 |
| Mouse bone marrow cells were stained with CD117 antibodies conjugated to PE (A) or APC (B) and analyzed by flow cytometry. |
| A |
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| B |
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| Products |
| CD117-PE, mouse |
- for 100 tests (1)
Download data sheet
130-091-730
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| CD117-APC, mouse |
- for 100 tests (1)
Download data sheet
130-091-729
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| (1) One test corresponds to fluorescent labeling of up to 107 cells in a total volume of 100 ÎĽL. |
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| References |
| 1. Orlic (2002) Int. J. Hematol. 76 Suppl.1: 144–145. |
| 2. Orlic et al. (2001) Proc. Natl. Acad. Sci. USA 98: 10344–10349.[8309] |
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