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| Description |
| Clone W8B2 recognizes the mesenchymal stromal cell antigen-1 (MSCA-1), a so far unknown antigen. MSCA-1 was shown to be restricted to mesenchymal stromal cells (MSCs) in the CD271bright population in bone marrow.1 These CD271brightCD45dim MSCs have a much higher clonogenic capacity compared to the CD271+CD45+ fraction in bone marrow1. Therefore, MSCA-1 is a suitable marker to identify MSCs with a high proliferative potential. |
| Applications |
| The Anti-MSCA-1 antibody can be used to identify and enumerate MSCs with high proliferative capacity from bone marrow or other tissue such as lipoaspirate by flow cytometry or fluorescence microscopy. The antibody is suitable for MACS® Control applications. |
| Clone | Isotype |
| W8B2 | Mouse IgG1 |
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| Figure 1 |
| Human bone marrow mononuclear cells (BM-MNCs) were stained with Anti-MSCA-1 (W8B2) antibodies conjugated to PE (A), APC (B), or Biotin (C). Cells stained with Anti-MSCA-1 (W8B2)-Biotin were additionally stained with Anti-Biotin-APC. Cells were counter-stained with CD45-FITC and analyzed by flow cytometry. |
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| B |
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| C |
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| Products |
| Anti-MSCA-1 (W8B2)-PE, human |
- for 100 tests (1)
Download datasheet
130-093-587
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| Anti-MSCA-1 (W8B2)-APC, human |
- for 100 tests (1)
Download datasheet
130-093-589
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| Anti-MSCA-1 (W8B2)-Biotin, human |
- for 100 tests (2)
Download datasheet
130-093-593
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| Anti-MSCA-1 (W8B2) pure, human |
- 100 µg in 1 mL
Download datasheet
130-093-595
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| (1) One test corresponds to fluorescent labeling of up to 107 cells in a total volume of 100 µL. |
| (2) One test corresponds to labeling of up to 107 cells in a total volume of 100 μL. |
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| References |
| 1. Bühring et al. (2007) Ann. NY Acad. Sci. 1106: 262–271. |
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