CD39
Description The CD39 antibody specifically recognizes the membrane-bound human CD39 antigen, which is expressed on an effector/memory-like subset of FoxP3+ regulatory T cells1. CD39 is an ectonucleotidase and catalyzes the hydrolysis of extracellular nucleotides, for example, ATP. In concert with CD73, which is an ecto-5’-nucleotidase, this can lead to the production of adenosine. High extracellular ATP concentrations indicate tissue injury and cell death and induce various pro-inflammatory responses in immune cells. Through its enzymatic activity, CD39 can contribute to the suppressive function of regulatory T cells, for example, by eliminating extracellular ATP or by generating adenosine, which has suppressive effects on various immune cells. Applications The CD39 antibody can be used to identify and enumerate CD39+ regulatory T cells and other cells expressing CD39. Cross-reactivity Rhesus monkey (Macaca mulatta) Clone Isotype MZ18-23C8 mouse IgG1		Figure 1 Human PBMCs were stained with CD4-FITC and CD39-PE (A). Furthermore, to evaluate CD39 expression on regulatory T cells, CD4+ T cells were enriched using the CD4+ T Cell Isolation Kit II and cells were stained with CD39-APC and Anti-FoxP3-PE (B). A B