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Cytokine detection antibodiesCytokine detection antibodiesCytokine detection antibodiesCytokine detection antibodies
Isotype control antibodiesIsotype control antibodiesIsotype control antibodiesIsotype control antibodies
Fc receptor blockingFc receptor blockingFc receptor blockingFc receptor blocking
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Cytokine detection
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Immunofluorescent amplification (FASER Kits)
Inside Stain Kit
Staining of apoptotic and dead cells
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CD39
Description
The CD39 antibody specifically recognizes the membrane-bound human CD39 antigen, which is expressed on an effector/memory-like subset of FoxP3+ regulatory T cells1. CD39 is an ectonucleotidase and catalyzes the hydrolysis of extracellular nucleotides, for example, ATP. In concert with CD73, which is an ecto-5’-nucleotidase, this can lead to the production of adenosine.
High extracellular ATP concentrations indicate tissue injury and cell death and induce various pro-inflammatory responses in immune cells.
Through its enzymatic activity, CD39 can contribute to the suppressive function of regulatory T cells, for example, by eliminating extracellular ATP or by generating adenosine, which has suppressive effects on various immune cells.
Applications
The CD39 antibody can be used to identify and enumerate CD39+ regulatory T cells and other cells expressing CD39.
Cross-reactivity
Rhesus monkey (Macaca mulatta)
Clone Isotype
MZ18-23C8mouse IgG1
 
Figure 1
Human PBMCs were stained with CD4-FITC and CD39-PE (A). Furthermore, to evaluate CD39 expression on regulatory T cells, CD4+ T cells were enriched using the CD4+ T Cell Isolation Kit II and cells were stained with CD39-APC and Anti-FoxP3-PE (B).
A
B
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Products
CD39-FITC, human
- for 100 tests (1)
Download datasheet
130-093-502
Qty.:
 

CD39-PE, human
- for 100 tests (1)
Download datasheet
130-093-503
Qty.:
 

CD39-APC, human
- for 100 tests (1)
Download datasheet
130-093-504
Qty.:
 

CD39-Biotin, human
- for 100 tests (2)
Download datasheet
130-093-505
Qty.:
 

CD39 pure, human
- 100 μg in 1 mL
Download datasheet
130-093-506
Qty.:
 

(1) One test corresponds to fluorescent labeling of up to 107 cells in a total volume of 100 μL.
(2) One test corresponds to labeling of up to 107 cells in a total volume of 100 μL.
Related products
CD4+CD25+ Regulatory T Cell Isolation Kit
CD4+CD25+CD127dim/– Regulatory T Cell Isolation Kit II, human (#130-094-775)
Anti-FoxP3 antibodies
References
1. Borsellino et al. (2007) Blood 110: 1225–1232.
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