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| Description |
Clone MZ18-24A9 specifically recognizes the human CD49d antigen. CD49d, also known as the α4 integrin chain or VLA-4α chain, is a 150 kDa cell adhesion protein that is directly involved in mononuclear leukocyte trafficking. Dimerized with β7 integrin, the resulting α4β7 integrin binds VCAM-1 (CD106), MAdCAM-1, and fibronectin to facilitate the rolling of leukocytes along vascular epithelium. In T cells, on ligation of MAdCAM-1, α4β7 integrin also provides costimulation of T cell receptor/CD3–mediated signaling.
CD49d is expressed on most mononuclear leukocytes, both in circulation or in lymphoid or other tissues, as well as on eosinophils and basophils. |
| Applications |
| Identification and enumeration of CD49d+ cells by flow cytometry or fluorescence microscopy. |
| Cross-reactivity |
- Rhesus monkey (Macaca mulatta)
- Cynomolgus monkey (Macaca fascicularis)
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| Clone | Isotype |
| MZ18-24A9 | Mouse IgG2b |
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| Figure 1 |
| Human PBMCs were stained with CD49d antibodies coupled to FITC (A), PE (B), or APC (C). Cells stained with CD49d-Biotin (D) were stained with Anti-Biotin-APC in addition. All samples were costained with CD4 antibody conjugates and then analyzed by flow cytometry. |
| A |
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| B |
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| C |
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| D |
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| Products |
| CD49d-FITC, human |
- for 100 tests (1)
Download datasheet
130-093-283
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| CD49d-PE, human |
- for 100 tests (1)
Download datasheet
130-093-282
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| CD49d-APC, human |
- for 100 tests (1)
Download datasheet
130-093-281
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| CD49d-Biotin, human |
- for 100 tests (2)
Download datasheet
130-093-280
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| CD49d pure, human |
- 100 µg in 1 mL.
Download datasheet
130-093-279
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| (1) One test corresponds to fluorescent labeling of up to 107 cells in a total volume of 100 µL. |
| (2) One test corresponds to labeling of up to 107 cells in a total volume of 100 µL. |
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