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| Description |
The CD28 antibody recognizes the human CD28 antigen, a type I transmembrane protein which is highly expressed on CD3+ thymocytes, most peripheral thymocytes and plasma cells. Binding of CD28 to its ligands CD80 or CD86 costimulates T cell effector function and T cell dependent antibody production in vitro and in vivo.
In the presence of antibodies directed against CD2 and CD3, CD28 antibodies stimulate T cell proliferation and cytokine production. |
| Applications |
| The CD28 antibody can be used to identify and enumerate CD28+ cells by flow cytometry or fluorescence microscopy. |
| Cross-reactivity |
- Rhesus monkey (Macaca mulatta)
- Cynomolgus monkey (Macaca fascicularis)
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| Clone | Isotype |
| 15E8 | Mouse IgG1 |
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| Figure 1 |
| Human PBMCs were stained with CD28 antibodies conjugated to PE (A), APC (B), or Biotin (C) and CD8 antibodies and analyzed by flow cytometry. Cells stained with CD28-Biotin were stained with Anti-Biotin-PE in addition. |
| A |
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| B |
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| C |
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| Products |
| CD28-PE, human |
For 100 tests (1)
Download data sheet
130-092-921
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| CD28-APC, human |
For 100 tests (1)
Download data sheet
130-092-923
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| CD28-Biotin, human |
For 100 tests (2)
Download data sheet
130-092-955
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| (1) One test corresponds to fluorescent labeling of up to 107 cell in a total volume of 100 µL. |
| (2) One test corresponds to labeling of up to 107 cell in a total volume of 100 µL. |
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