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| Description |
The Anti-KIR2D antibody recognizes the killer immunoglobulin-like receptor (KIR) 2D subtype. KIRs are expressed on CD56dimCD16+ natural killer (NK) cells and a subset of CD8+ T cells. KIRs contribute to the regulation of NK cell–mediated cytotoxicity. They are monomeric receptors possessing high allelic polymorphism with either 2 or 3 Ig-like extracellular domains (KIR2D or KIR3D, respectively). According to the length of their cytoplasmic tail, KIRs can be subdivided in long-tailed inhibitory KIRs and short-tailed activating KIRs.
The Anti-KIR2D antibody recognizes all KIRs bearing 2 extracellular Ig-like domains, and also both activating and inhibitory KIR isoforms (KIR2DS and KIR2DL, respectively). |
| Applications |
| Identification and enumeration of KIR2D+ human cells by flow cytometry or fluorescence microscopy. |
| Cross-reactivity |
- Rhesus monkey (Macaca mulatta)
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| Clone | Isotype |
| NKVFS1 | Mouse IgG1 |
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| Figure 1 |
| Human PBMCs were stained with Anti-KIR2D antibody conjugated to PE (A), APC (B) or Biotin (C), as well as CD56-PE or -APC, and analyzed by flow cytometry. Cells stained with Anti-KIR2D-Biotin were additionally stained with Anti-Biotin-PE. |
| A |
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| B |
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| C |
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| Products |
| Anti-KIR2D-PE, human |
For 100 tests (1)
Download data sheet
130-092-688
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| Anti-KIR2D-APC, human |
For 100 tests (1)
Download data sheet
130-092-687
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| Anti-KIR2D-Biotin, human |
For 100 tests (2)
Download data sheet
130-092-904
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| Anti-KIR2D pure, human |
100 µg in 1 mL
Download data sheet
130-092-689
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| (1) One test corresponds to fluorescent labeling of up to 107 cells in a total volume of 100 µL. |
| (2) One test corresponds to labeling of up to 107 cells in a total volume of 100 µL. |
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