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| Description |
| Clone BAT221 recognizes CD314 (NKG2D), a cell surface receptor of the type II transmembrane receptor NKG2 family. It is expressed on NK cells, CD8+ α/β T cells, and γ/δ T cells. Though NKG2D itself possesses no intrinsic signaling capability, ligand engagement while associated to the adaptor proteins DAP10 or DAP12 induces cytolytic activation in NK cells as well as costimulation in certain T cell populations. Ligands for NKG2D are stress-inducible MHC Class I-related MICA, MICB, and UL16-binding proteins, expressed predominantly on epithelial cells and numerous carcinomas. |
| Applications |
| The antibody is suitable for identification and enumeration of NKG2D+ cells by flow cytometry or fluorescence microscopy. |
| Cross-reactivity |
- Rhesus monkey (Macaca mulatta)
- Cynomolgus monkey (Macaca fascicularis)
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| Clone | Isotype |
| BAT221 | Mouse IgG1 |
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| Figure 1 |
| Human PBMCs were stained with CD314 (NKG2D)-PE (A), -APC (B), or -Biotin (C), and CD56-APC or -PE, respectively. Cells stained with CD314 (NKG2D)-Biotin were additionally stained with Anti-Biotin-APC. Cells were analyzed by flow cytometry. |
| A |
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| B |
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| C |
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| Products |
| CD314 (NKG2D)-PE, human |
for 100 tests (1)
Download data sheet
130-092-672
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| CD314 (NKG2D)-APC, human |
for 100 tests (1)
Download data sheet
130-092-673
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| CD314 (NKG2D)-Biotin, human |
for 100 tests (2)
Download data sheet
130-092-825
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| CD314 (NKG2D) pure, human |
100 µg in 1 mL
Download data sheet
130-092-686
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| (1) One test corresponds to fluorescent labeling of up to 107 cells in a total volume of 100 µL |
| (2) One test corresponds to labeling of up to 107 cells in a total volume of 100 µL |
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