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| Description |
| Clone 11PB6 recognizes CD158a (KIR2DL1) and CD158h (KIR2DS1), two members of the killer immunoglobulin-like receptor (KIR) family expressed on CD56dimCD16+ natural killer (NK) cells and CD8+ T cells. KIRs contribute to the regulation of NK cell–mediated cytotoxicity. They are monomeric receptors possessing high allelic polymorphism with either 2 or 3 Ig-like extracellular domains. According to the length of their cytoplasmic tail, KIRs can be subdivided in long-tailed inhibitory KIRs and short-tailed activating KIRs. CD158a (KIR2DL2) and CD158h (KIR2DS1) have identical extracellular portions but differ in their transmembrane and cytoplasmic regions. CD158a (KIR2DL1) is involved in the transduction of an inhibitory signal. CD158h (KIR2DS1) is an activating receptor. The ligands of CD158a (KIR2DL1) are HLA-Cw4 and related molecules (HLA-Cw2, -Cw5, -Cw6). |
| Applications |
| The antibody is suitable for the identification and enumeration of CD158a/h (KIR2DL1/DS1)+ cells by flow cytometry and fluorescence microscopy. |
| Clone | Isotype |
| 11PB6 | Mouse IgG1 |
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| Figure 1 |
| Human PBMCs were stained with CD158a/h (KIR2DL1/DS1)-FITC (A), -PE (B) or -APC (C) and CD56-PE or -APC, respectively. Cells stained with CD158a/h (KIR2DL1/DS1)-Biotin were stained with Anti-Biotin-APC in addition (D). Cells were analyzed by flow cytometry. |
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| Products |
| CD158a/h (KIR2DL1/DS1)-FITC, human |
for 100 tests (1)
Download data sheet
130-092-811
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| CD158a/h (KIR2DL1/DS1)-PE, human |
for 100 tests (1)
Download data sheet
130-092-684
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| CD158a/h (KIR2DL1/DS1)-APC, human |
for 100 tests (1)
Download data sheet
130-092-685
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| CD158a/h (KIR2DL1/DS1)-Biotin, human |
for 100 tests (2)
Download data sheet
130-092-683
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| CD158a/h (KIR2DL1/DS1) pure, human |
100 µg in 1 mL
Download data sheet
130-092-682
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| (1) One test corresponds to fluorescent labeling of up to 107 cells in a total volume of 100 µL. |
| (2) One test corresponds to labeling of up to 107 cells in a total volume of 100 µL. |
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