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| Description |
| Clone DX11 recognizes CD226 (DNAM-1), a 65 kDa transmembrane glycoprotein expressed on T cells, NK cells, platelets, monocytes, and a subset of B cells. It is also expressed by a subset of CD3+ thymocytes. The surface association of CD226 (DNAM-1) with LFA-1 on NK cells and T cells permits the transduction of cytolytic signals upon binding of CD226 (DNAM-1) to its ligands CD155 (PVR) and CD112 (Nectin-2). |
| Applications |
| The antibody is suitable for identification and enumeration of CD226 (DNAM-1)+ cells by flow cytometry or fluorescence microscopy. |
| Cross-reactivity |
- Rhesus monkey (Macaca mulatta)
- Cynomolgus monkey (Macaca fascicularis)
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| Clone | Isotype |
| DX11 | Mouse IgG1 |
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| Figure 1 |
| Human PBMCs were stained with CD226 (DNAM-1) antibodies conjugated to PE (A), or APC (B), as well as CD56-APC or CD56-PE and analyzed by flow cytometry. Cells stained with CD226 (DNAM-1)-Biotin (C) were also stained with Anti-Biotin-FITC. Cell debris and dead cells were excluded from the analysis based on scatter signals and PI fluorescence. |
| A |
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| B |
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| C |
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| Products |
| CD226 (DNAM-1)-PE, human |
for 100 tests (1)
Download data sheet
130-092-476
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| CD226 (DNAM-1)-APC, human |
for 100 tests (1)
Download data sheet
130-092-477
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| CD226 (DNAM-1)-Biotin, human |
for 100 tests (2)
Download data sheet
130-092-478
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| CD226 (DNAM-1) pure, human |
100 µg in 1 mL
Download data sheet
130-092-479
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| (1) One test corresponds to fluorescent labeling of up to 107 cells in a total volume of 100 µL. |
| (2) One test corresponds to labeling of up to 107 cells in a total volume of 100 µL. |
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