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| Description |
| CD117 (AC126) recognizes the human CD117 antigen. Clone AC126 does not interfere with stem cell factor (SCF)-binding and recognizes an epitope identical or in close proximity to the epitope recognized by the CD117 clone 104D2, but is different from the epitope recognized by the CD117 clone A3C6E2. CD117 (also known as c-kit or SCF receptor) is a 145 kDa cell surface glycoprotein with tyrosine kinase activity. This molecule is suggested to be involved in signaling, activation, and proliferation of cells. The CD117 antigen is expressed on about 1–3% of PBMCs and cord blood cells and on up to 10% of bone marrow cells. Around 25% of CD117+ cells were found to express CD133 and CD34. CD117 is further expressed on basophils, myeloid dendritic cells, TCRα/β+ T cells, CD19+ B cells, and CD56+ NK cells1, as well as on mast cells, melanocytes, and AML (acute myeloid leukemia) blasts2. |
| Applications |
| CD117 (AC126) is suitable for the identification and enumeration of CD117+ cells by flow cytometry or fluorescence microscopy. Clone AC126 can also be used for the indirect isolation of CD117+ cells using CD117 (AC126)-PE and Anti-PE MicroBeads. Clone AC126 does not interfere with the binding of SCF to CD117. |
| Clone | Isotype |
| AC126 | Mouse IgG1 |
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| Figure 1 |
| Human cord blood mononuclear cells (CB-MNCs) were stained with CD117 (AC126)-PE and CD133/2 (293C3)-APC, and analyzed by flow cytometry. |
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| Products |
| CD117 (AC126)-PE, human |
for 100 tests (1)
Download data sheet
130-091-735
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| (1) One test corresponds to fluorescent labeling of up to 107 cells in a total volume of 100 ÎĽL. |
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| MACS References |
| 1. Guth et al. (1995) (Abstract) 9th International Congress of Immunology. |
| 2. Bühring et al. (1991) Leukemia 5: 854–860.[8508] |
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