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| Description |
The Anti-CLA antibody recognizes the cutaneous lymphocyte-associated antigen (CLA), a specialized glycoform of P-selectin glycoprotein ligand-1. It serves as a ligand for selectins, including CD62E (ELAM-1) and CD62L (LECAM-1). CLA has been proposed to be a mediator of skin-specific Th lymphocyte homing.
In peripheral blood, CLA is not only expressed on skin homing memory/effector T cells but also on memory/effector B cells, NK cells, blood dendritic cells and monocytes. It is furthermore found on Langerhans cells in the skin. |
| Applications |
| The Anti-CLA antibody is suitable for identification and enumeration of CLA+ cells by flow cytometry or fluorescence microscopy. |
| Clone | Isotype |
| HECA-452 | Rat IgM |
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| Figure 1 |
| Human PBMCs were stained with Anti-CLA antibodies conjugated to FITC (A), PE (B) or Biotin (C). Cells were also stained with CD4-PE or -APC. For Anti-CLA Biotin, Anti-Biotin-APC was used as a secondary antibody. |
| A |
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| B |
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| C |
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| Products |
| Anti-CLA-FITC, human |
for 100 tests (1)
Download data sheet
130-091-636
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| Anti-CLA-PE, human |
for 100 tests (1)
Download data sheet
130-091-635
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| Anti-CLA-Biotin, human |
for 100 tests (2)
Download data sheet
130-091-634
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| Anti-CLA pure, human |
100 µg in 1 mL
Download data sheet
130-092-629
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| (1) One test corresponds to fluorescent labeling of up to 107 cells in a total volume of 100 µL. |
| (2) One test corresponds to labeling of up to 107 cells in a total volume of 100 µL. |
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