CD62L
Description Clone 145/15 recognizes the human CD62L antigen, a 74 kDa glycoprotein and a member of the selectin family of cell surface molecules. CD62L is also known as L-selectin, LECAM-1, or LAM-1 and binds a series of glycoproteins including CD34, GlyCAM-1, and MAdCAM-1. CD62L is important for homing of naive lymphocytes via endothelial venules to peripheral lymph nodes and Peyer’s patches. The CD62L antigen also contributes to the recruitment of leukocytes from the blood to areas of inflammation. Most hematopoietic cells express CD62L, including most peripheral blood B cells, T cells, monocytes, granulocytes, and some myeloid cells from bone marrow, and thymocytes. CD62L is continuously endoproteolytically cleaved from the cell surface neutrophils and lymphocytes (shedding). Proteolysis is accelerated, for example, after antigenic activation of T cells. Applications The CD62L antibody can be used to identify and enumerate CD62L+ cells by flow cytometry. This antibody is suitable for MACS® Control applications. For further details, please refer to the data sheet of the separation reagent. Clone Isotype 145/15 Mouse IgG1		Figure 1 Human PBMCs were stained with CD62L-FITC (A), CD62L-PE (B) or CD62L-APC (C) and CD4. Cells were analyzed by flow cytometry. a b c

Search this site

Advanced Search