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| Description |
The CD16 antibody recognizes the human CD16 antigen, a glycoprotein of 50–80 kDa in size that is expressed in two isoforms. The transmembrane isoform is found on NK cells, macrophages, and mast cells.
The glycosylphosphatidylinositol (GPI)-linked form is present on neutrophils. The CD16 antigen is a low-affinity receptor for aggregated IgG. The transmembrane form plays a role in signal transduction, NK cell activation, and antibody-dependent cellular cytotoxicity. Clone VEP13 recognizes both the extracellular domain of the transmembrane isoform as well as the GPI-linked form of the CD16 antigen. |
| Applications |
| The CD16 antibody can be used to identify and enumerate CD16+ cells by flow cytometry or fluorescence microscopy. This antibody is also suitable for MACS® Control applications. For further details, please also refer to the data sheet of the separation reagent. |
| Cross-reactivity |
- Rhesus monkey (Macaca mulatta)
- Cynomolgus monkey (Macaca fascicularis)
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| Clone | Isotype |
| VEP13 | Mouse IgM |
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| Figure 1 |
| Human lysed blood was stained with CD16-FITC (A), CD16-PE (B), and CD16-APC (C) and analyzed by flow cytometry. |
| A |
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| B |
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| C |
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| Products |
| CD16-FITC, human |
for 100 tests (1)
Download data sheet
130-091-244
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| CD16-PE, human |
for 100 tests (1)
Download data sheet
130-091-245
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| CD16-APC, human |
for 100 tests (1)
Download data sheet
130-091-246
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| (1) One test corresponds to fluorescent labeling of up to 107 cells in a total volume of 100 ÎĽL. |
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