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| Description |
| The CD123 antibody recognizes the human CD123 antigen which is also known as IL-3 receptor α-chain and is the primary low-affinity subunit of the IL-3 receptor. CD123 associates with CD131, the common β-chain of the IL-3, IL-5, and GM-CSF receptor, to form the high-affinity IL-3 receptor. The IL-3 receptor is involved in cell signaling for cell growth and differentiation. In peripheral blood, the CD123 antigen is expressed at high levels only on plasmacytoid dendritic cells and basophilic granulocytes but at low levels also on monocytes, eosinophilic granulocytes, myeloid dendritic cells, and subsets of hematopoietic progenitor cells. |
| Applications |
| The CD123 antibody can be used to identify and enumerate CD123+ cells by flow cytometry or fluorescence microscopy. |
| Clone | Isotype |
| AC145 | Mouse IgG2a |
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| Figure 1 |
| Human PBMCs were stained with CD123-FITC (A), CD123-PE (B) or CD123-APC (C) and CD303 (BDCA-2)-FITC or -PE, respectively. Cells were analyzed by flow cytometry. |
| A |
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| B |
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| C |
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