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 - Efficient: high yield of isolated CD56+ cells
- Gentle: excellent viability rates
- Time-saving: purified cells are immediately ready for any downstream application
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| Description |
| CD56 MicroBeads were developed for the positive selection or depletion of natural killer (NK) cells from human PBMCs or single-cell suspensions from tissues. The CD56 antigen is expressed by most NK cells and a minor T cell subset (CD3+CD56+ NKT cells). Upon activation of NK cells, the surface expression of CD56 is increased. |
| Details |
Downstream applications
CD56+ cells are used in studies on NK cell development, proliferation, or cytotoxic activity as well as in analysis of signal transduction and related molecular processes1–3.
CD56 may also be used for the enrichment of embryonic stem cell–derived cardiomyocytes cells after in vitro differentiation4 as well as the direct selection stem and progenitor cells from muscle tissue5,6. |
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| Figure 1 |
| Separation of CD56+ cells from PBMCs using CD56 MicroBeads, an LS Column, and a MidiMACS™ Separator. |
| PBMCs before separation |
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| Isolated CD56+ cells |
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| Details |
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| References |
| 1. Fletcher et al. (1998) J. Immunol. 161: 2365–2374. |
| 2. Doherty et al. (1999) J. Immunol. 163: 2314–2321. |
| 3. Kumaki et al. (2001) Blood 98: 1464–1468. |
| 4. Xu, S. et al. (2006) Stem Cells and Dev. 15: 631–639. |
| 5. Sinanan, A. et al. (2004) Biotechnol. Appl. Biochem. 40: 25–34. |
| 6. De Luna, N. et al. (2006) J. Biol. Chem. 281: 17092–17098. |
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