|
|
 |
|
| Description |
| The CD127 MicroBead Kit has been developed for the positive selection or depletion of CD127+ cells from human PBMCs. |
| Details |
Background information
CD127, the α-chain of the IL-7 receptor, is a type I membrane glycoprotein. Signaling of IL-7 through the IL-7R requires both IL-7Rα and the common cytokine gamma chain (γc).1 CD127 can be identified on immature B cells through the early pre-B stage, on thymocytes, and on most mature T cells with transient down-regulation upon activation.2,3 On regulatory T cells CD127 is absent4 and its expression is inversely correlated with FoxP3 expression and suppressive function.5,6 CD127 is also used by thymic stromal derived lymphopoietin (TSLP) as part of a complex.1
Human regulatory T cells can be isolated, for example, by using the CD4+CD25+CD127dim/– Regulatory T Cell Isolation Kit, human. |
| | |
|
|
| Favorites / Prices |
Request prices or add products to your favorite list.
|
| Details |
|
| References |
| 1. Fry and Mackall (2002) Blood 99: 3892–3904. |
| 2. Sudo et al. (1993) J. Immunol. 90: 9125–9129. |
| 3. Armitage et al. (1991) Adv. Exp. Med. Biol. 292: 121–130. |
| 4. Cupedo et al. (2005) Eur. J. Immunol. 35: 383–390. |
| 5. Seddiki et al. (2006) J. Exp. Med. 203: 1693–1700. |
| 6. Liu et al. (2006) J. Exp. Med. 203: 1701–1711. |
|
|
|
© 1999 - 2012 Miltenyi Biotec ¦ Terms & conditions ¦ Legal notes
|
