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| Description |
CD57 MicroBeads were developed for the positive selection or depletion of CD57+ cells from human PBMCs, body fluids, or single-cell suspensions from tissue (e.g. lymphoid tissues).
The CD57 antigen, also known as HNK-1 or Leu-7, is an oligosaccharide antigenic moiety bound to surface proteins of certain cell types. CD57 is present on 15–20% of PBMCs, including subsets of NK cells and T cells and some neural cell types.1,2 |
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Background information
CD57 has been shown to be expressed on late-stage CD8+ effector cells3 and terminally differentiated NK cells.
The frequency of CD57+ T lymphocytes is raised in a variety of diseases, for example, in rheumatoid arthritis4. Its expression is also increased on proliferation-incompentent or chronically activated CD8+ T cells in persistent viral infections, such as HIV.5
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| Figure 1 |
| CD57+ cells were isolated from human PBMCs using CD57 MicroBeads, an MS Column, and a MiniMACS™ Separator. Cells were stained with CD57-APC and analyzed by flow cytometry. |
| PBMCs before separation |
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| CD57- cells |
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| CD57+ cells |
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| Details |
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| References |
| 1. Mechtersheimer et al. (1991) Cancer Res. 51: 1300–1307. |
| 2. Ong et al. (2002) J. Biol. Chem. 277: 18182–18190. |
| 3. Brenchley et al. (2003) Blood 101: 2711–2720. |
| 4. Dupuy d'Angeac et al. (1993) Arthritis Rheum. 36: 608–612. |
| 5. Palmer, B.E. et al. (2005) J. Immunol. 175: 8415–8423. |
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