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 - Unrivaled: excellent purity and unmatched recovery
- Time-saving: cells can be immediately used for downstream applications
- Reliable: proven in a plethora of publications
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| Description |
| CD3 MicroBeads were developed for positive selection or depletion of CD3+ T cells from peripheral blood, bronchial lavage, cell culture, or various tissues such as lymphoid, nasal, and tumor tissue. |
| Details |
Background information
CD3 is expressed on all T cells and CD56+ NKT cells, and is associated with the T cell receptor. 70–80% of human peripheral blood lymphocytes and 65–85% of thymocytes are CD3+. The epitope recognized by CD3 MicroBeads is located on the CD3ε chain.
Downstream applications
T cells isolated by MACS® Technology have been used for various studies, e.g., on T cell cytotoxicity, T cell activation1, HIV infectivity2, signal transduction, and surface marker expression. |
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| Details |
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| References |
| 1. Pitti et al. (1998) Nature 396: 699-703. |
| 2. Heath et al. (1995) Nature 377: 740-744. |
| 3. Lorenzen et al. (1999) J. Exp. Med.190: 1049-1058. |
| 4. Heidenreich and Jovin (1996) J. Neurol. 243: 57-62. |
| 5. Klein et al. (1994) J. Exp. Med.180: 1383-1393. |
| 6. Nicoll et al. (2003) Eur. J. Immunol. 33: 1642-1648. |
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