The PIQORâ„¢ SkinPatho Microarray comprises altogether 1,132 genes associated with pathological expression changes in human skin. Within the frame of Miltenyi Biotec's dermatology research program, more than 800 consented patient biopsies in four inflammatory diseases, three skin cancers and healthy skin were collected and gene expression profiling analyses were performed.
The selected genes reflect the outcome of whole genome and PIQOR Skin Microarray analyses. Main topics are disease-specific gene expression changes of malignant melanoma and psoriasis. For instance, melanoma-associated antigens, S100 genes, or genes from the psoriasis susceptibility locus are part of the microarray. The collection is completed by important genes related to basal and squamous cell carcinoma, lichen planus, and contact and atopic dermatitis.
Overall, PIQOR SkinPatho Microarray consists of genes associated with inflammation and malignant transformation in human skin. Relevant genes for cytokine signaling, stress, cell cycling, and signal transduction are included. Important surface markers, structural proteins, and extracellular matrix proteins round off the configuration.
The PIQOR SkinPatho Microarray is available as a convenient microarray kit or within the scope of Microarray Service.
Please see download area for "Further information"
On request - please inquire for delivery time. |
| Gene Overview |
Human: 1,132 genes
Genes are spotted in quadruplicates.
Apoptosis/Inflammation
Caspases, STATs, etc.
Cell cycle
Cyclins and receptors, etc.
Cytokine signaling
Cytokines/chemokines and receptors, TGF beta family members, etc.
DNA repair and metabolism
Extracellular matrix proteins
Matrix metalloproteinases, collagens, etc.
Immune system: immunoglobulins, MHC genes, etc.
Oncology
Melanoma-associated genes, SEREX genes, tumor-associated genes, etc.
Psoriasis susceptibility genes
Signal transduction
Hormones, growth factors, secreted factors, etc.
Structural proteins
Keratins, integrins, etc.
Surface markers (CD nomenclature)
Synaptic proteins
Gap junction proteins, etc.
Transcription factors
NFκB metabolism, etc.
Transporter
ABC transporter, etc.
Six housekeeping genes and six controls
ACTA2, CYPA, GAPDH, HPRT, TUBA, TUBB, herring sperm DNA, salt, four artificial control RNAs |
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| Figure 1 |
| PIQOR SkinPatho Microarray |
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