The PIQOR™ Oncology Microarray has been developed with international experts in the field of immuno-oncology, within the framework of the European Cancer Immunome Program (EUCIP, www.eurice.de/eucip). The results of this joint approach provide new insights into cancer-associated genotypic and phenotypic alterations.
PIQOR Oncology Microarray represents an upgrade of PIQOR EUCIP Microarrays, which have been used to profile hundreds of breast, lung, and colon tumor as well as normal samples. The microarray consists of immuno-oncologically relevant and tumor-associated genes with a focus on more than 600 SEREX-derived genes.
The SEREX technique1 comprises the serological analysis of cDNA expression libraries to identify human tumor antigens eliciting a spontaneous humoral immune response in cancer patients. Therefore, SEREX genes may play an important role in tumor growth.
In addition, genes were selected from previously published data and public databases, related to different cancer types like breast, lung, colon, kidney, prostate, and liver cancer, leukemia and lymphoma. These genes are involved in important oncological pathways, for example apoptosis pathway, major MAP Kinase pathways, NFκB and JAK-STAT pathways.
PIQOR Oncology Microarray is available as a convenient microarray kit or within the scope of Microarray Service.
Please see download area for "Further information"
On request - please inquire for delivery time. |
| Gene overview |
Human: 1503 genes
Genes are spotted in quadruplicates.
Apoptosis and stress
BCL2 family members, caspases, heat shock proteins, MAP kinases, multidrug resistance proteins, NFκB metabolism, TNF family, TNF receptor family, proteasomal proteins, TRAILs, tumor marker, etc.
Cell cycle and DNA repair
BRCA1, CCND1, cyclins and cyclin dependent kinases, histone deacylases, p53, PCNA, UVRAG, etc.
Cytokine signaling
Chemokines, chemokine receptors, cytokines, cytokine receptors, TGFβ family members, etc.
Extracellular matrix and structural proteins
Collagens, integrins, laminins, matrix metalloproteases, proteoglycans, serpin type of serine protease inhibitors, TIMPs, etc.
Hormones growth factors
BMPs, bone morphogenic proteins, growth differentiation factors, GDFs, IL1B, VEGF, etc.
Ligands, receptors, surface markers
Clusters of differentiation (CDs), CD3D, IL2RB, seven transmembrane receptors, TNR receptors, TNFR1, etc.
Metabolism (energy, nucleotide, protein, lipid, or carbohydrate)
Apolipoproteins, phospholipases, protein kinases, proteasomal subunits, etc.
SEREX genes
DKFZP434A17, MAGEA3, NY-CO-10, and many transcriptionally uncharacterized SEREX genes, etc.
Transporter
ATP-binding cassette transporter (ABC), sodium and glutamate transporter, etc.
Transcription factors and signal transduction
Basic helix-loop-helix and leucine zipper transcription factors, forkhead and homebox family members, JAK-STAT family, high motility and zinc finger transcription factors, etc.
Six housekeeping genes and six controls
ACTA2, CYPA, GAPDH, HPRT, TUBA, TUBB, herring sperm DNA, salt, four artificial control RNAs |
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| Figure 1 |
| PIQOR Oncology Microarrays |
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