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| Overview |
| CD1a MicroBeads have been developed for positive selection of CD1a+ dendritic cells from epidermis (Langerhans cells), dermis, lung, mucosa, and other non-lymphoid tissues or for further purification of CD1a+ dendritic cells generated ex vivo from CD34+ or CD133+ hematopoietic progenitor cells. |
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Background information
The CD1a antigen is a member of the CD1 family of proteins, which are structurally related to MHC class I proteins and mediate the presentation of non-peptide antigens to T cells.1
Applications
CD1a MicroBeads were used, for example, for the isolation of Langerhans cells from epidermis2 or for isolation of hematopoietic progenitor cell-derived dendritic cells.3 |
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| Figure 1 |
| Dendritic cells were generated by culturing isolated CD133+ cells in the presence of Flt-3 Ligand, SCF, GM-CSF, TNF-α, and TGF-β for 10 days. Thereafter, CD1a+ cells were isolated by using CD1a MicroBeads and stained with CD1a-FITC. |
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| References |
| 1. Brigl and Brenner (2004) Annu Rev Immunol. 22: 817-890. |
| 2. Simon et al. (1995) Exp. Dermatol. 4: 155-161. |
| 3. Ye et al. (1996) Bone Marrow Transplant. 18: 997-1008. |
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