| Description |
CD1a MicroBeads were developed for positive selection of CD1a+ dendritic cells from epidermis (Langerhans cells), dermis, lung, mucosa, and other non-lymphoid tissues or for further purification of CD1a+ dendritic cells generated ex vivo from CD34+ or CD133+ hematopoietic progenitor cells.
The CD1a antigen is a member of the CD1 family of proteins, which are structurally related to MHC class I proteins and mediate the presentation of non-peptide antigens to T cells.1 |
| Applications |
| CD1a MicroBeads were used, for example, for the isolation of Langerhans cells from epidermis2 or for isolation of hematopoietic progenitor cell-derived dendritic cells.3 |
| |
| Figure 1 |
| Dendritic cells were generated by culturing isolated CD133+ cells in the presence of Flt-3 Ligand, SCF, GM-CSF, TNF-α, and TGF-β for 10 days. Thereafter, CD1a+ cells were isolated by using CD1a MicroBeads and stained with CD1a-FITC. |
 |
|
|
