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| Overview |
The VarioMACS™ Separator gives the flexibility to separate small samples as well as samples of up to 2×109 total cells. Various MACS Columns can be used with the height-adjustable VarioMACS Separator:
The MS Column Adapter is required to insert MS Columns into the magnetic field of the VarioMACS Separator, and the LS Column Adapter is required to insert LS, LD or Whole Blood Columns. |
| Details |
Background information
The VarioMACS™ Separator contains a powerful permanent magnet that induces a high-gradient magnetic field within MACS® Columns – a field strong enough to retain cells labeled with even small amounts of MACS MicroBeads.
Applications
In addition to many applications using MACS® MicroBeads, the VarioMACS Separator in combination with LD or CS Columns1 has been used for the enrichment of Plasmodium falciparum-infected erythrocytes without magnetic labeling2. The malaria parasites digest red blood cell hemoglobin, resulting in the formation of hemozoin. The paramagnetic properties of hemozoin allow magnetic isolation of red blood cells without the need for further labeling. |
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| Figure 1 |
| The VarioMACS™ Separator shown with a CS Column and a rack. |
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| Figure 2 |
| An MS Column placed in the magnetic field of a VarioMACS™ Separator using an MS Column Adapter. |
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| Details |
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| Products |
| VarioMACS Separator |
Components
- 1 VarioMACS Separator for MS, LS, LD, and CS Columns
- 1 VarioMACS glass stand with height adjustable mounting for the magnet
- 1 Pair of pliers for use with CS Columns
Download datasheet
130-090-282
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| References |
| 1. Uhlemann et al. (2000) MACS&more 4-2: 7-8. |
| 2. Staalsoe et al. (1999) Cytometry 35: 329-336. |
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