|
|
 |
| Anti-MHC Class II (OX6) MicroBeads |
|
| Overview |
| Anti-MHC Class II (OX6) MicroBeads have been developed for the positive selection or depletion of rat cells expressing the major histocompatibility complex (MHC) class II. |
| Details |
Background information
The monoclonal antibody recognizes a non-polymorphic determinant of the MHC class II antigen RT1B, the rat homolog of the murine I-A antigen. MHC class II (RT1B) is expressed on antigen-presenting cells (APCs), notably on B cells, dendritic cells, and on most monocytes and macrophages where it is up-regulated upon activation. After activation, epithelial cells, endothelial cells as well as microglia and NK cells also become MHC class II+.
Downstream applications
Isolated MHC class II+ cells can be used for functional assays on antigen presentation and T cell stimulation. Additionally, Anti‑MHC Class II MicroBeads can be used for the enrichment of untouched T cells from lymph nodes by depletion of MHC class II+ cells. |
| |
| Figure 1 |
| Isolation of T cells by depletion of MHC II (RT1B)+ cells from rat lymph nodes using Anti-MHC Class II (OX6) MicroBeads, a MiniMACS™ Separator, and an MS Column. |
| A: Lymph node cells before separation |
 |
| B: Isolated T cells after depletion of OX6+ cells |
 |
|
|
|
|
| Favorites / Prices |
Request prices or add products to your favorite list.
|
| Details |
|
| Products |
| Anti-MHC Class II (OX6) MicroBeads, rat |
- for 109 total cells
Download datasheet
130-090-759
|
|
|
|
© 1999 - 2012 Miltenyi Biotec ¦ Terms & conditions ¦ Legal notes
|
