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| Overview |
| Rat CD45RA MicroBeads were developed for positive selection or depletion of B cells from blood, peripheral lymphoid organs, or from non-lymphoid tissues. |
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Background information
The CD45RA isoform is B cell lineage–specific. It is neither expressed on thymocytes nor on any peripheral T cell subset. CD45RA was not detected on B cell progenitors in bone marrow.
Downstream applications
B cells separated with CD45RA MicroBeads can be used for analysis of B cell migration into non-lymphoid organs after infections, for evaluation of B cell responses after allograft transplantation, or to study the role of B cells in autoimmune diseases, such as arthritis or diabetes. Isolated B cells were used for adoptive transfer experiments to study autoimmunity and tolerance induction after xenogeneic thymus transplantation.1 Furthermore, isolated B cells were used for molecular analysis.2 |
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| Details |
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| References |
| 1. Yan et al. (2003) J. Immunol. 170: 5936-5946. |
| 2. Lombardi et al. (2001) J. Immunol. 166: 1635-1640. |
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