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  • MACS® Cell Analysis
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Cell separation reagents Cell separation reagents
  for human cells
  for non-human primate cells
  for mouse cells
  for rat cells
  T cells
  B cells
  Dendritic cells
  Antigen-presenting cells
  Neural cells
  for indirect magnetic labeling
  for apoptotic and dead cells
  for isolation of mitochondria
Manual cell separation Manual cell separation
Automated cell separation Automated cell separation
MACS® Technology MACS® Technology
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CD45R MicroBeads
Overview
Rat CD45R MicroBeads have been developed for positive selection or depletion of rat B cells from bone marrow, peripheral lymphoid organs, and non-lymphoid tissue.
Details
Background information
The CD45R antigen is expressed throughout B cell development from the pro-B cell stage on, but it is down-regulated during the differentiation of B cells into plasma cells. Expression levels of CD45R are different among distinct B cell subpopulations. Memory B cells are CD45Rlow/-. CD45R is also weakly expressed on a small subset of peripheral T cells, but is not detected on thymocytes.

Downstream applications
B cells isolated from bone marrow or peripheral lymphoid organs can be used for in vitro or ex vivo analysis of B cell lymphopoiesis and B cell migration. B cells purified with CD45R MicroBeads can be used for studies on the mechanism and regulation of immunoglobulin gene rearrangement.
Columns
For positive selection: MS, LS, XS, or autoMACS® Columns; for depletion: LD, CS, D, or autoMACS Columns.
 
Figure 1
Isolation of B cells from rat spleen using CD45R MicroBeads, a MiniMACS™ Separator, and an MS Column.
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Details
Products
CD45R MicroBeads, rat
- for 109 total cells
Download datasheet
130-090-495
Qty.:
 

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