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| Overview |
| Rat CD45R MicroBeads have been developed for positive selection or depletion of rat B cells from bone marrow, peripheral lymphoid organs, and non-lymphoid tissue. |
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Background information
The CD45R antigen is expressed throughout B cell development from the pro-B cell stage on, but it is down-regulated during the differentiation of B cells into plasma cells. Expression levels of CD45R are different among distinct B cell subpopulations. Memory B cells are CD45Rlow/-. CD45R is also weakly expressed on a small subset of peripheral T cells, but is not detected on thymocytes.
Downstream applications
B cells isolated from bone marrow or peripheral lymphoid organs can be used for in vitro or ex vivo analysis of B cell lymphopoiesis and B cell migration. B cells purified with CD45R MicroBeads can be used for studies on the mechanism and regulation of immunoglobulin gene rearrangement. |
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