CD57 ( #130-096-530 #130-092-174 #130-092-139 #130-092-141 #130-092-620 )

CD57

Overview

The antibody is suitable for the identification and enumeration of human CD57⁺ cells by flow cytometry and fluorescence microscopy. CD57, also known as HNK-1 or Leu-7, is present in blood on 15-20% of mononuclear cells. This frequency is altered in a variety of diseases.

Details

Background information
Clone TB03 specifically recognizes human CD57. CD57, also known as HNK-1 or Leu-7, is an antigenic oligosaccharide moiety detected on extracellular proteins of certain cell types. In blood, CD57 is found on 15–20% of mononuclear cells, including subsets of NK and T cells, though not on erythrocytes, monocytes, granulocytes, or platelets. Also, CD57 expression can be found on a variety of neural cell types.
CD57 has been shown to be expressed on late stage effector CD8⁺ T cells. The frequency of CD57⁺ T lymphocytes is raised in a variety of diseases. CD57 expression is also increased on chronically activated CD8⁺ T cells in persistent viral infections, such as HIV.

Clone	Isotype
TB03	Mouse IgM

Figure 1

Human PBMCs were stained with CD57 antibodies conjugated to FITC (A), PE (B), APC (C) or VioBlue (D) and analyzed by flow cytometry. Cells stained with CD57-Biotin were additionally stained with Anti-Biotin-PE (D).