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| Overview |
The antibody is suitable for identification and enumeration of CD158i (KIR2DS4)+ human cells by flow cytometry or fluorescence microscopy.
The family of killer immunoglobulin-like receptors (KIR) contributes to the regulation of NK cell-mediated cytotoxicity. |
| Details |
Background information
Clone JJC11.6 recognizes CD158i (KIR2DS4), a member of the killer immunoglobulin-like receptor (KIR) family expressed on natural killer (NK) cells. CD158i (KIR2DS4) provides an activation signal for NK lytic activity upon interaction with its ligand, HLA-Cw4, in an antigen-independent manner.
KIRs are monomeric receptors possessing high allelic polymorphism with either 2 or 3 Ig-like extracellular domains. The receptor family can be subdivided functionally according to the length of their cytoplasmic tail in inhibitory and activating KIRs. |
| Clone | Isotype |
| JJC11.6 | Mouse IgG1 |
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| Figure 1 |
| Human PBMCs were stained with CD158i (KIR2DS4) antibodies conjugated to PE (A), APC (B), or Biotin (C), as well as CD56 conjugates, and analyzed by flow cytometry. Cells stained with CD158i (KIR2DS4)-Biotin were stained with Anti-Biotin-PE in addition. |
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| B |
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| C |
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| Products |
| CD158i (KIR2DS4)-PE, human |
- for 100 tests (1)
Download datasheet
130-092-680
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| CD158i (KIR2DS4)-APC, human |
- for 100 tests (1)
Download datasheet
130-092-681
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| CD158i (KIR2DS4)-Biotin, human |
- for 100 tests (2)
Download datasheet
130-092-898
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| CD158i (KIR2DS4) pure, human |
- 100 µg in 1 mL
Download datasheet
130-092-679
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| (1) One test corresponds to fluorescent labeling of up to 107 cells in a total volume of 100 µL. |
| (2) One test corresponds to labeling of up to 107 cells in a total volume of 100 µL. |
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