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| Overview |
| The CD11c antibody is suitable for the identification and enumeration of CD11c+ cells by flow cytometry and fluorescence microscopy. CD11c, also known as integrin integrin αX or CR4, has been reported to play a role in adhesion and CTL killing through its interactions with fibrinogen, CD54, and iC3b. |
| Details |
Background information
This CD11 antibody reacts with human CD11c, a 145–150 kD type I transmembrane glycoprotein also known as integrin αX or CR4. It is expressed on monocytes, macrophages, NK cells, granulocytes, myeloid dendritic cells (MDCs), and subsets of T and B cells.
On myeloid dendritic cells, CD11c is highly expressed on type 1 myeloid dendritic cells (CD1c (BDCA-1)+ CD123low MDC1s) and low on type 2 myeloid dendritic cells (CD1c(BDCA-1)– CD123– MDC2s). |
| Clone | Isotype |
| MJ4-27G12 | Mouse IgG2b |
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| Figure 1 |
| Human PBMCs were stained with CD11c antibodies conjugated to FITC (A), PE (B), APC (C), or VioBlue (D) as well as CD1c (BDCA-1)-PE or -APC and analyzed by flow cytometry. CD11c-Biotin labeled cells (E) were stained with Anti-Biotin-APC in addition. |
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| B |
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| C |
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| D |
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| E |
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| Products |
| CD11c-FITC, human |
- for 100 tests (1)
Download datasheet
130-092-410
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| CD11c-PE, human |
- for 100 tests (1)
Download datasheet
130-092-411
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| CD11c-APC, human |
- for 100 tests (1)
Download datasheet
130-092-412
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| CD11c-VioBlue, human |
- for 100 tests (1)
130-097-328
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| CD11c-Biotin, human |
- for 100 tests (2)
Download datasheet
130-092-413
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| CD11c pure, human |
- 100 µg in 1 mL
Download datasheet
130-092-414
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| (1) One test corresponds to fluorescent labeling of up to 107 cells in a total volume of 100 µL. |
| (2) One test corresponds to labeling of up to 107 cells in a total volume of 100 µL. |
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