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| Overview |
| The CD71 antibody has been developed for the detection and quantification of CD71+ cells by flow cytometry or fluorescence microscopy. |
| Details |
Background information
The CD71 antibody recognizes the transferrin receptor, which is essential for iron transport into proliferating cells. CD71 is expressed on marrow stromal cells (MSCs) from bone marrow1, on activated T and B lymphocytes, macrophages, and all proliferating cells. It is upregulated on lymphocytes during proliferative responses to antigens or mitogens but is not expressed on resting lymphocytes. CD71 is present on reticulocytes and erythroid progenitors in fetal liver, cord blood, and peripheral blood, yet it is lost as these differentiate to mature erythrocytes.2,3,4 |
| Clone | Isotype |
| AC102 | Mouse IgG2a |
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| Figure 1 |
| Human cord blood mononuclear cells (CB-MNCs) were stained with CD71-PE (A) or -APC (B) and CD45-FITC and analyzed by flow cytometry. |
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| B) |
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| Products |
| CD71-PE, human |
- for 100 tests (1)
Download datasheet
130-091-728
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| CD71-APC, human |
- for 100 tests (1)
Download datasheet
130-091-727
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| (1) One test corresponds to fluorescent labeling of up to 107 cells in a total volume of 100 μL. |
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| References |
| 1. Pittenger et al. (1999) Science 284: 143–147. |
| 2. Judd et al. (1980) J. Exp. Med. 152: 1430–1435. |
| 3. Loken et al. (1987) Blood 69: 255–263. |
| 4. Phillips et al. (1984) J. Exp. Med. 159: 993–1008. |
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