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| Overview |
The monoclonal Anti-Melanoma (MCSP) antibody binds to melanoma cells from human tissues or cell lines and is used for:
- detection of disseminated melanoma cells, e.g. in peripheral blood1,2 or bone marrow by flow cytometry or fluorescence microscopy,
- analysis of single-cell suspensions of skin biopsies or primary skin cell cultures by flow cytometry or fluorescence microscopy.
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| Details |
Background information
The Anti-Melanoma (MCSP) antibody recognizes the melanoma-associated chondroitin sulfate proteoglycan (MCSP) antigen, also known as high molecular weight melanoma-associated antigen. MCSP is expressed on the majority (>90%) of human melanoma tissues and melanoma cell lines but not on carcinoma cells, fibroblastoid cells, and cells of hematopoietic origin3-6. |
| Clone | Isotype |
| EP-1 | Mouse IgG1 |
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| Figure 1 |
| Human peripheral blood leukocytes mixed with cells from a melanoma cell line (SK-Mel-28) were stained using Anti-Melanoma (MCSP)-PE (A) or Anti-Melanoma (MCSP)-APC (B) and analyzed by flow cytometry. |
| A |
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| B |
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| Products |
| Anti-Melanoma (MCSP)-PE, human |
| For research use only |
- for 100 tests (1)
Download datasheet
130-091-225
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| Anti-Melanoma (MCSP)-APC, human |
| For research use only |
- for 100 tests (1)
Download datasheet
130-091-252
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| (1) One test corresponds to fluorescent labeling of up to 107 cells in a total volume of 100 μL. |
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| References |
| 1. Benez et al. (1999) J. Clin. Lab. Anal. 13: 229-233. |
| 2. Siewert et al. (2000) Recent Results in Cancer Research 158: 51-60 |
| 3. Morgan et al. (1981) Hybridoma 1: 27–36 |
| 4. Bumol and Reisfeld (1982) Proc. Natl. Acad. Sci. USA 79: 1245–1249 |
| 5. Bumol et al. (1984) J. Biol. Chem. 259: 12733–12741 |
| 6. Pluschke et al. (1996) Proc. Natl. Acad. Sci. USA 93: 9710–9715 |
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