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| Overview |
| The LT20 antibody clone can be used to identify and enumerate human and non-human primate CD20+ B lineage cells and CD20+ malignant B cells by flow cytometry or fluorescence microscopy. |
| Details |
Background information
The antibody recognizes the CD20 antigen, a non-glycosylated transmembrane protein of 33–37 kDa that is expressed on B lineage cells from the pre-B cell stage to the B cell lymphoblast stage. The antigen is further expressed on most malignant B cells. CD20 is not found on early B cell progenitors or plasma cells. Oligomers of CD20 form a Ca2+ channel and might function in the regulation of local responses during B cell activation. |
| Cross-reactivity |
This antibody is tested to react with - Rhesus monkey (Macaca mulatta)
- Cynomolgus monkey (Macaca fascicularis)
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| Clone | Isotype |
| LT20 | Mouse IgG1 |
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| Figure 1 |
| Human peripheral blood lymphocytes were stained with CD20 antibodies conjugated to FITC (A), PE (B), VioBlue (C), VioGreen (D) or PerCP (E) and analyzed by flow cytometry. |
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| B |
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| D |
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| E |
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| Figure 2 |
| Rhesus monkey PBMCs were stained with CD20-FITC and analyzed by flow cytometry. |
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| Figure 3 |
| Cynomolgus monkey PBMCs were stained with CD20-FITC and analyzed by flow cytometry. |
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