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| Overview |
The antibody is suited for the identification and enumeration of cells expressing either CD158e, CD158k, or both, by flow cytometry or fluorescence microscopy.
The family of killer immunoglobulin-like receptors (KIR) contributes to the regulation of NK cell–mediated cytotoxicity. |
| Details |
Background information
Clone 5.133 recognizes CD158e (KIR3DL1) and CD158k (KIR3DL2), two members of the killer immunoglobulin-like receptor (KIR) family which recognizes subsets of HLA alleles. Expression is found mainly on CD56dimCD16+ natural killer (NK) cells but also on a subset of CD8+ T cells. They are monomeric receptors possessing high allelic polymorphism with either 2 or 3 Ig-like extracellular domains. According to the length of their cytoplasmic tail, KIRs can be subdivided in inhibitory KIRs and activating KIRs. |
| Clone | Isotype |
| 5.133 | mouse IgG1 |
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| Human PBMCs were stained with CD158e/k (KIR3DL1/DL2)-PE (A) or -Biotin (B) and CD56-APC. Cells stained with CD158e/k (KIR3DL1/DL2)-Biotin were stained with Anti-Biotin-PE in addition. Cells were analyzed by flow cytometry using the MACSQuant® Analyzer. |
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| B |
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| Products |
| CD158e/k (KIR3DL1/DL2)-PE, human |
- for 100 tests (1)
Download datasheet
130-095-205
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| CD158e/k (KIR3DL1/DL2)-Biotin, human |
- for 100 tests (2)
Download datasheet
130-095-201
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| CD158e/k (KIR3DL1/DL2) pure, human |
- 100 µg in 1 mL
Download datasheet
130-095-199
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| (1) One test corresponds to fluorescent labeling of up to 107 cells in a total volume of 100 µL. |
| (2) One test corresponds to labeling of up to 107 cells in a total volume of 100 µL. |
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