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Cancer researchers utilize a broad spectrum of techniques to seek insight into the diverse spectrum of cancer types and cellular changes that happen during cancer progression. From learning about DNA damage response and cell cycle defects to understanding tumor progression and metastasis, flow cytometry can provide valuable insights into the mechanisms that facilitate cancer formation and prevention.
The MACSQuant assays for cancer research include:
- Apoptosis measurement
- Cell cycle analysis
- Proliferation
- Fluorescent protein analysis
- Identification and characterization of Cancer Stem Cells
- Identification and characterization of circulating tumor cells
- Solid tumor cell analysis (post-dissociation)
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References
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| Chaudhuri, AA et al. Oncomir miR-125b regulates hematopoiesis by targeting the gene Lin28A (2012) Proc Natl Acad Sci U S A. |
| Della Donna, L et al. Radioresistance of prostate cancer cells with low proteasome activity (2011) The Prostate. |
| Dos Santos, C et al. Anti-tumorgenic effects of a mutant of the heparin affin regulatory peptide (HARP) on the U87 MG glioblastoma cell line (2010) Int. J. Cancer. |
| Fellenberg, J et al. A microRNA signature differentiates between giant tumor derived neoplastic stromal cells and mesenchymal stem cells (2012) Cancer Lett. |
| Gabitass, RF et al. Elevated myeloid-derived suppressor cells in pancreatic esophageal and gastric cancer are an independent prognostic factor and are associated with significant elevation of the Th2 cytokine interleikin-13 (2011) Cancer Immunol Immunother. |
| Heinemann, L et al. The effect of cell cycle synchronization on tumor sensitivity to reovirus oncolysis (2010) Molecular Therapy. |
Jutzy, JM et al. Tumor-released Survivin induces a type-2 T cell
response and decreases cytotoxic T cell function,
in vitro (2012) Cancer Microenviron. |
| Khan, S et al. Survivin is released from cancer cells via exosomes (2010) Apoptosis. |
| Lagadec, C et al. Radiation-induced reprogramming of breast cancer cells (2012) Stem Cells. |
| Lagadec, C et al. Oxygen levels do not determine radiation survival of breast cancer stem cells (2012) PLoS One. |
| Mkrtichyan, M et al. Cancer-testis antigen, BORIS based vaccine delivered by dendritic cells is extremely effective against a very aggressive and highly metastatic mouse mammary carcinoma (2011) Cell Immunol. |
| Morishita, N et al. Activation of Akt is associated with poor prognosis and chemotherapeutic resistance in pediatric B-precursor acute lymphoblastic leukemia (2011) Pediatr Blood Cancer. |
| Nishimori, H. et al. Synthetic retinoid Am80 ameliorates chronic graft-versus-host disease by downregulating Th1 and Th17 (2011) Blood. |
| Stamatopoulous, B et al. The histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) induces apoptosis, downregulated the CXCR4 chemokine receptor and impairs migration of chronic lymphocytic leukemia cells (2010) Haematologica. |
| Stamatopoulous, B et al. AMD3100 disrupts the cross-talk between chronic lymphocytic leukemia cells and a mesenchymal stromal or nurse-like cell-based microenvironment: preclinical evidence for its association with chronic lymphocytic leukemia treatments (2011) Haematologica. |
| Stamova, S et al. Unexpected recombinations in single chain bispecific anti-CD3-anti-CD33 antibodies can be avoided by a novel linker module (2011) Mol Immunol. |
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