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| Embryonic stem cells and induced pluripotent stem cells |
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Embryonic stem (ES) and induced pluripotent stem (iPS) cells have the capacity to self-renew and to differentiate into all cell types of the body. They promise an essentially unlimited supply of specific cell types for basic research, drug testing, and possibly for future transplantation therapies.To investigate these cells it is crucial to use homogenous cell populations. MACS® Technology enables the isolation of numerous particular cell types and subsets at high purity.
Hematopoietic stem cells (HSCs) can be isolated from differentiated ES cells by using, for example, the following cell surface markers:
• CD34
• CD43
• CD133
Endothelial progenitor cells (EPCs) can be isolated from ES cells by using, for example:
• CD34
• CD31
Miltenyi Biotec also offers numerous products for the enrichment of various neural cell types that can be derived from ES cells, such as:
• CD133+ neural stem cells,
• PSA-NCAM+ neuronal-restricted precursors,
• A2B5+ glial-restricted precursors,
• CD11b+ microglial cells,
• CD271 (LNGFR, p75 NTR)+ Schwann cells and motor neurons.
Removal of feeder cells – MACS Technology enables the separation of ES or iPS cells from feeder cells.
Enrichment of undifferentiated, pluripotent ESCs – MACS Technology is a straightforward tool for the enrichment of pluripotent stem cells. ES and iPS cells undergoing spontaneous differentiation can be depleted using Anti-SSEA-1 MicroBeads. Alternatively, pluripotent cells can be positively selected according to expression of pluripotency-associated markers, such as SSEA-3, SSEA-4, TRA-1-60, or TRA-1-81.
Efficient generation of iPS cells – The fast magnetic isolation of fully reprogrammed cells with high expression levels of SSEA-3 may enhance the generation of iPS cells.
For more information on products for research on mouse ES and iPS cells, click here. |
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| Anti-SSEA-1 (CD15) MicroBeads |
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| Pluripotent Stem Cell MicroBeads |
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| Anti-TRA-1-60 MicroBead Kit |
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