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| Isolate and analyze viable Th17 cells! |
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Isolate, analyze and differentiate Th17 cells!
Th17 cells, a T helper cell subset distinct from Th1 and Th2 cells, preferentially produce interleukin-17 (IL-17, or IL-17A), IL-17F, IL-21, and IL-22 and express the c-type lectin like receptor CD161. Th17 cells are involved in the recruitment of neutrophils to control early stages of infections to extracellular bacteria and fungi. IL-17 and Th17 cells have been shown to play an important role in immune-mediated diseases.
Viable human and mouse IL-17–secreting cells can now be isolated and analyzed using the unique MACS® Cytokine Secretion Assays.
Human IL-17-secreting cells:
Mouse IL-17-secreting cells:
In the presence of several cytokines, including TGF-β, IL-1β, IL-6, and IL-21, isolated human naive CD4+ T cells can be differentiated in vitro into Th17 cells. For cell stimulation the T Cell Activation/Expansion Kit has been used.1
1Acosta-Rodriguez et al. (2007) Nat. Immunol. 8: 942–948. |
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