Stemgent introduces the new mRNA Reprogramming System which was developed based on the recent publication in Cell Stem Cell by Warren et al in November 2010. With conversion efficiencies and kinetics equally or superior to other methods, the mRNA reprogramming technology is a significant leap forward in the drive to safely and effectively reprogram mature human cells.
The Stemgent mRNA Reprogramming System consists of the mRNA Reprogramming Factors Set, the Pluriton™ mRNA Reprogramming Medium, B18R protein, and the Stemgent validated mRNA reprogramming protocol. This system enables non-viral, non-integrating, clinically-relevant reprogramming of human cells. Messenger RNA-based reprogramming completely eliminates the risk of genomic integration and mutagenesis inherent to DNA and viral-based technologies while offering a highly robust and efficient reprogramming system.
Non-integrative technology eliminates risk of insertional mutagenesis
Transient protein expression levels easily regulated
New, novel xeno-free reprogramming medium
Faster iPS cell generation, colonies appear within 16 days
Reproducible reprogramming protocol using normal and diseased cells
In an exclusive interview on June 6, 2011 with Dr. Rudolf Jaenisch, a professor of biology at the Massachusetts Institute of Technology and a founding member of the Whitehead Institute, Dr. Jaenisch discusses the current advancements in cellular reprogramming. In the first of a three part series, Dr. Jaenisch talks about the advantages of mRNA reprogramming and the future challenges of using iPS cells in the field of stem cell research.
mRNA Protocol Poster Get the 'Validated mRNA Reprogramming Protocol' poster as presented at ISSCR 2011.
mRNA User Manual The newly revised mRNA Reprogramming User Manual outlines the six easy steps for mRNA reprogramming with new getting started guidelines, day-by-day protocol, materials list, and much more.
